Research Use Only. Peptides Lab UK supplies research-grade materials for in-vitro laboratory research only. Nothing on this page is medical advice or an instruction for human or animal use, and no product sold on this website is a medicine.
What is Epitalon?
Epitalon (also Epithalon; sequence Ala-Glu-Asp-Gly, AEDG) is a synthetic tetrapeptide modelled on a pineal gland extract. Its research literature comes largely from a small number of groups, mostly using cell and animal models. It is not an authorised medicine in the UK.
Published research
A 2025 review summarises reported effects of epitalon in cell and animal studies, including on gene expression, antioxidant activity and telomerase-related endpoints. In-vitro work has examined effects on gene expression and protein synthesis during neuronal differentiation. Independent replication and controlled human data remain limited.[1,2,3]
Limitations of the evidence
Much of the available literature is preclinical (cell and animal models) or comes from small numbers of research groups. Findings in defined experimental systems cannot be extrapolated to other settings, and this page does not provide dosing, administration or human-use information.
Laboratory handling and storage
Lyophilised peptides are generally stored sealed, protected from light and moisture, at low temperature as specified on the certificate of analysis. Once reconstituted for in-vitro work, solutions are typically kept refrigerated and used within a validated stability window. Researchers should follow their institution’s procedures and the batch documentation (HPLC purity and mass-spectrometry identity) supplied with each lot.
UK regulatory status
In the UK, medicines are regulated by the Medicines and Healthcare products Regulatory Agency (MHRA). Research-grade compounds sold by Peptides Lab UK are supplied strictly for laboratory research; they are not medicinal products, are not manufactured to medicinal GMP standards and must not be used in humans or animals.
Related research pages
- peptide reconstitution guide
- UK research-peptide sourcing guide
- Epitalon UK complete research guide
- Research peptides explained
References
- Araj SK et al. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025; 26(6). doi:10.3390/ijms26062691 PMID: 40141333.
- Khavinson V et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020; 25(3). doi:10.3390/molecules25030609 PMID: 32019204.
- Gatta M et al. The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy. Stem Cell Rev Rep. 2025; 21(6):1822-1834. doi:10.1007/s12015-025-10911-x PMID: 40493162.
Disclaimer: All products sold by Peptides Lab UK are for laboratory research use only. Not for human or veterinary use, not for consumption, and not intended to diagnose, treat, cure or prevent any disease. This page is an educational literature summary and is not medical advice.
